Sorting it out: Regulation of exosome loading
نویسندگان
چکیده
منابع مشابه
Sorting it out
The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alterna...
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Sorting it out, without clathrin lathrin-independent endocytosis is revealing itself at last. Intermediary organelles in this pathway have been difficult to identify, due in part to a dearth of markers and, until recently, difficulties in blocking the clathrin-dependent process. But now, has identified a set of endosomes that are uniquely C involved in clathrin-independent trafficking. Nichols'...
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Machine learning concepts can find applications in many domains. We describe here one such application to the problem of fingerprint verification. In biometric verification using fingerprints, one often has to handle large archives of fingerprint images. When verifying an individual fingerprint, it is important to have a fast method at hand that selects suitable candidate images out of a large ...
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Ion and water transport by the kidney is continually adjusted in response to physiological cues. Selective endocytosis and endosomal trafficking of ion transporters are increasingly appreciated as mechanisms to acutely modulate renal function. Here, we discuss emerging paradigms in this new area of investigation.
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From an early age, we sort jellybeans with friends, placing watermelon flavor at the top of our list, and pushing licorice to the bottom. We contribute to larger-scale ranking operations when we rate a product in an online catalog. Given the prevalence of human-powered ranking in the digital realm, it is important to study the most effective user interfaces and algorithms for eliciting rankings...
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ژورنال
عنوان ژورنال: Seminars in Cancer Biology
سال: 2014
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2014.04.009